| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase 2, mitochondrial |
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| Ligand | BDBM50206483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454745 (CHEMBL886767) |
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| IC50 | 402000±n/a nM |
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| Citation |  Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase 2, mitochondrial |
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| Name: | Thymidine kinase 2, mitochondrial |
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| Synonyms: | KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31013.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1333885 |
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| Residue: | 265 |
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| Sequence: | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
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| BDBM50206483 |
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| n/a |
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| Name | BDBM50206483 |
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| Synonyms: | (2R,3S,4R,5R)-2-(5-((E)-2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-3-yl 2-methoxyacetate | CHEMBL399413 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17BrN2O8 |
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| Mol. Mass. | 421.197 |
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| SMILES | COCC(=O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C=CBr)c(=O)[nH]c1=O |w:18.19| |
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| Structure | 
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