Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 1 |
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Ligand | BDBM50213496 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_456153 (CHEMBL888163) |
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IC50 | 1600000±n/a nM |
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Citation | Zhang, J; Zhang, P; Liu, X; Fang, K; Lin, G Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors. Bioorg Med Chem Lett17:3769-73 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 1 |
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Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Mus musculus |
Description: | ChEMBL_788602 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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BDBM50213496 |
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n/a |
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Name | BDBM50213496 |
Synonyms: | (R)-1-(2-(benzhydrylthio)ethyl)piperidine-3-carboxylic acid hydrochloride | CHEMBL537448 |
Type | Small organic molecule |
Emp. Form. | C21H25NO2S |
Mol. Mass. | 355.494 |
SMILES | OC(=O)[C@@H]1CCCN(CCSC(c2ccccc2)c2ccccc2)C1 |
Structure |
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