| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
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| Ligand | BDBM50213502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456153 (CHEMBL888163) |
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| IC50 | 240000±n/a nM |
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| Citation |  Zhang, J; Zhang, P; Liu, X; Fang, K; Lin, G Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors. Bioorg Med Chem Lett17:3769-73 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 1 |
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| Name: | Sodium- and chloride-dependent GABA transporter 1 |
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| Synonyms: | GABA transporter | GABA transporter 1 | Gabt1 | Gat-1 | Gat1 | SC6A1_MOUSE | Slc6a1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67006.26 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_788602 |
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| Residue: | 599 |
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| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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| BDBM50213502 |
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| n/a |
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| Name | BDBM50213502 |
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| Synonyms: | (R)-1-(2-(dip-tolylmethylthio)ethyl)piperidine-3-carboxylic acid hydrochloride | CHEMBL539347 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29NO2S |
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| Mol. Mass. | 383.547 |
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| SMILES | Cc1ccc(cc1)C(SCCN1CCC[C@H](C1)C(O)=O)c1ccc(C)cc1 |
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| Structure | 
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