| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
|---|
| Ligand | BDBM50221573 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_457662 (CHEMBL923939) |
|---|
| IC50 | 6223±n/a nM |
|---|
| Citation |  Tao, ZF; Li, G; Tong, Y; Stewart, KD; Chen, Z; Bui, MH; Merta, P; Park, C; Kovar, P; Zhang, H; Sham, HL; Rosenberg, SH; Sowin, TJ; Lin, NH Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors. Bioorg Med Chem Lett17:5944-51 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 |
|---|
| Name: | Serine/threonine-protein kinase Chk1 |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54443.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_166295192 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
|---|
| BDBM50221573 |
|---|
| n/a |
|---|
| Name | BDBM50221573 |
|---|
| Synonyms: | 6,7-dimethoxy-3-(4-morpholin-4-yl-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole | CHEMBL245603 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23N3O3 |
|---|
| Mol. Mass. | 377.4363 |
|---|
| SMILES | COc1cc2Cc3c(n[nH]c3-c3ccc(cc3)N3CCOCC3)-c2cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
