| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14-alpha demethylase |
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| Ligand | BDBM50213693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_459077 (CHEMBL925157) |
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| Ki | 600±n/a nM |
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| Citation |  Jain, KS; Kathiravan, MK; Somani, RS; Shishoo, CJ The biology and chemistry of hyperlipidemia. Bioorg Med Chem15:4674-99 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14-alpha demethylase |
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| Name: | Lanosterol 14-alpha demethylase |
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| Synonyms: | CP51A_RAT | CYPLI | Cyp51 | Cyp51a1 | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14-alpha demethylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56717.47 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_52075 |
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| Residue: | 503 |
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| Sequence: | MVLLGLLQSGGSVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKS
PPYIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS
KNEDLNAEEVYGRLTTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAK
EYFKSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL
LPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDE
IAGMLIGLLLAGQHTSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDL
NLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD
FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFP
SVNYTTMIHTPENPVIRYKRRSK
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| BDBM50213693 |
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| n/a |
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| Name | BDBM50213693 |
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| Synonyms: | (3S,5S,8R,9S,10S,13R,14R,17R)-5,13-dimethyl-17-((R)-6-methylheptan-2-yl)-14-(oxiran-2-ylmethyl)-hexadecahydro-1H-cyclopenta[a]phenanthrene-3,10-diol | CHEMBL398686 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H52O3 |
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| Mol. Mass. | 460.7321 |
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| SMILES | CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(CC3CO3)[C@@H]3CC[C@@]4(C)C[C@@H](O)CC[C@]4(O)[C@H]3CC[C@]12C |w:13.12| |
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| Structure | 
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