| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
|---|
| Ligand | BDBM50214607 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_459093 (CHEMBL926261) |
|---|
| IC50 | 554±n/a nM |
|---|
| Citation |  Bruno, RD; Njar, VC Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem15:5047-60 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
|---|
| Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
|---|
| Synonyms: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_HUMAN | CYP1ALPHA | CYP27B | CYP27B1 | Cytochrome P450 27B1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56522.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15528 |
|---|
| Residue: | 508 |
|---|
| Sequence: | MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP
EPGAAPVRPKTRTVLVPERSINLQFLDR
|
|
|
|---|
| BDBM50214607 |
|---|
| n/a |
|---|
| Name | BDBM50214607 |
|---|
| Synonyms: | CHEMBL541423 | MK-24 | MK-24(S)-S(O)(NH)Ph |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H39NO3S |
|---|
| Mol. Mass. | 481.69 |
|---|
| SMILES | C[C@H](CC=S(N)(=O)c1ccccc1)C1=CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |t:14| |
|---|
| Structure | 
|
|---|
Search and Browse
