| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM50031853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_467320 (CHEMBL939915) |
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| IC50 | 100±n/a nM |
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| Citation |  Wiemer, AJ; Yu, JS; Shull, LW; Barney, RJ; Wasko, BM; Lamb, KM; Hohl, RJ; Wiemer, DF Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. Bioorg Med Chem16:3652-60 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM50031853 |
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| n/a |
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| Name | BDBM50031853 |
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| Synonyms: | ((3E,7E)-4,8,12-Trimethyl-1-phosphono-trideca-3,7,11-trienyl)-phosphonic acid | (2E,6E)-farnesylbisphosphonate | 2E,6E-farnesyl bisphosphonate | CHEMBL86513 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H30O6P2 |
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| Mol. Mass. | 380.3533 |
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| SMILES | [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]\[#6]=[#6](/P([#8])([#8])=O)P([#8])([#8])=O |
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| Structure | 
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