| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50373832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468550 (CHEMBL930974) |
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| IC50 | >150000±n/a nM |
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| Citation |  Lewis, LM; Sheffler, D; Williams, R; Bridges, TM; Kennedy, JP; Brogan, JT; Mulder, MJ; Williams, L; Nalywajko, NT; Niswender, CM; Weaver, CD; Conn, PJ; Lindsley, CW Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorg Med Chem Lett18:885-90 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51555.53 |
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| Organism: | RAT |
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| Description: | P10980 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50373832 |
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| n/a |
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| Name | BDBM50373832 |
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| Synonyms: | CHEMBL429780 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24ClN3O2 |
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| Mol. Mass. | 373.876 |
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| SMILES | CCN1CCN(CC1)c1ccc(NC(=O)COc2ccccc2)cc1Cl |
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| Structure | 
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