| Reaction Details |
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 | Report a problem with these data |
| Target | Segment polarity protein dishevelled homolog DVL-1 |
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| Ligand | BDBM50373849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468588 (CHEMBL931111) |
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| IC50 | >500000±n/a nM |
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| Citation |  Mahindroo, N; Punchihewa, C; Bail, AM; Fujii, N Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorg Med Chem Lett18:946-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Segment polarity protein dishevelled homolog DVL-1 |
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| Name: | Segment polarity protein dishevelled homolog DVL-1 |
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| Synonyms: | DSH homolog 1 | DVL1 | DVL1_HUMAN | Dishevelled-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75195.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_468588 |
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| Residue: | 695 |
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| Sequence: | MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVK
EEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSF
HPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSAST
ALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSI
TDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDM
LLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDP
AAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVR
VMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFL
RHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPY
QYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGS
GSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGG
PPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
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| BDBM50373849 |
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| n/a |
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| Name | BDBM50373849 |
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| Synonyms: | CHEMBL255988 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N2O3 |
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| Mol. Mass. | 376.4483 |
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| SMILES | Cc1cc2[nH]c(C(=O)NCC3CC3)c(CCc3ccccc3)c2cc1C(O)=O |
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| Structure | 
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