Ki Summary

Reaction Details

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Target

Protein-arginine deiminase type-4

Ligand

BDBM50266539

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_468733 (CHEMBL929915)

540000±n/a nM

Citation

Knuckley, B; Luo, Y; Thompson, PR Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem16:739-45 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Protein-arginine deiminase type-4

Name:

Protein-arginine deiminase type-4

Synonyms:

PAD4 | PADI4 | PADI4_HUMAN | PADI5 | PDI5

Type:

Enzyme Catalytic Domain

Mol. Mass.:

74078.90

Organism:

Homo sapiens (Human)

Description:

gi_216548487

Residue:

663

Sequence:

MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKK
KSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCAD
ITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDM
SLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMV
PGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTP
NTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAP
HKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRG
KEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVP
APDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNS
FVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPK
PFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWN
MVP

BDBM50266539

n/a

Name

BDBM50266539

Synonyms:

(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide | CHEMBL456066 | CHLORTETRACYCLINE | chlorotetracycline

Type

Small organic molecule

Emp. Form.

C22H23ClN2O8

Mol. Mass.

478.88

SMILES

CN(C)[C@H]1[C@@H]2C[C@H]3C(C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O)C(=O)[C@]2(O)C(=O)C(C(N)=O)C1=O |r|

Structure