Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50031203 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_469207 (CHEMBL932239) |
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Ki | 0.1±n/a nM |
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Citation | Maryanoff, BE; Costanzo, MJ Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem16:1562-95 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50031203 |
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n/a |
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Name | BDBM50031203 |
Synonyms: | 2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyryl}-benzooxazole-6-carboxylic acid methyl ester | CHEMBL334978 | methyl 2-((S)-2-((S)-1-((S)-2-(4-(carbamoyl)benzamido)-3-methylbutanoyl)pyrrolidine-2-carboxamido)-3-methylbutanoyl)benzo[d]oxazole-6-carboxylate |
Type | Small organic molecule |
Emp. Form. | C38H40ClN5O10S |
Mol. Mass. | 794.27 |
SMILES | COC(=O)c1ccc2nc(oc2c1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)C(C)C)C(C)C |
Structure |
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