| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM50374472 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_469369 (CHEMBL932846) |
|---|
| IC50 | 630±n/a nM |
|---|
| Citation |  Morytko, MJ; Betschmann, P; Woller, K; Ericsson, A; Chen, H; Donnelly-Roberts, DL; Namovic, MT; Jarvis, MF; Carroll, WA; Rafferty, P Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists. Bioorg Med Chem Lett18:2093-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68403.50 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q64663 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
|
|
|
|---|
| BDBM50374472 |
|---|
| n/a |
|---|
| Name | BDBM50374472 |
|---|
| Synonyms: | CHEMBL255534 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H37N5O |
|---|
| Mol. Mass. | 495.6584 |
|---|
| SMILES | Cc1ccccc1N=C(NC#N)N1CCN(C(C1)c1ccccc1)C(=O)CC12CC3CC(CC(C3)C1)C2 |w:7.7,TLB:36:27:34:30.31.32,26:27:34:30.31.32,THB:36:31:28.27.35:34,32:31:28:35.33.34,32:33:28:30.36.31| |
|---|
| Structure | 
|
|---|
Search and Browse
