Reaction Details | |||
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Target | MAP kinase-activated protein kinase 2 | ||
Ligand | BDBM50374691 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_469831 (CHEMBL949020) | ||
IC50 | 45±n/a nM | ||
Citation | Goldberg, DR; Choi, Y; Cogan, D; Corson, M; DeLeon, R; Gao, A; Gruenbaum, L; Hao, MH; Joseph, D; Kashem, MA; Miller, C; Moss, N; Netherton, MR; Pargellis, CP; Pelletier, J; Sellati, R; Skow, D; Torcellini, C; Tseng, YC; Wang, J; Wasti, R; Werneburg, B; Wu, JP; Xiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett18:938-41 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
MAP kinase-activated protein kinase 2 | |||
Name: | MAP kinase-activated protein kinase 2 | ||
Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 45579.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49137 | ||
Residue: | 400 | ||
Sequence: |
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BDBM50374691 | |||
n/a | |||
Name | BDBM50374691 | ||
Synonyms: | CHEMBL437033 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27N5O3S | ||
Mol. Mass. | 465.568 | ||
SMILES | CC1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC(C)n4c3c2)n1 |w:27.28,(10.96,-17.91,;12.5,-17.94,;13.29,-16.62,;14.82,-16.64,;15.57,-17.98,;14.79,-19.31,;13.25,-19.28,;17.12,-18,;18.02,-16.76,;17.4,-15.35,;19.56,-16.92,;20.32,-18.25,;21.83,-17.93,;21.99,-16.41,;23.32,-15.64,;24.66,-16.41,;24.65,-17.95,;25.99,-15.64,;25.99,-14.1,;27.32,-13.33,;28.65,-14.09,;30.12,-13.62,;31.03,-14.86,;32.56,-15.02,;33.47,-13.78,;33.18,-16.44,;32.26,-17.69,;30.73,-17.52,;29.82,-18.75,;30.11,-16.11,;28.65,-15.64,;27.32,-16.41,;20.59,-15.78,)| | ||
Structure |