| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM50105618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_470479 (CHEMBL951323) |
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| IC50 | 15000±n/a nM |
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| Citation |  Zhu, T; Jiao, Y; Chen, YD; Wang, X; Li, HF; Zhang, LY; Lu, T Pharmacophore identification of Raf-1 kinase inhibitors. Bioorg Med Chem Lett18:2346-50 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 73082.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50105618 |
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| n/a |
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| Name | BDBM50105618 |
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| Synonyms: | 1-(5-tert-butyl-2-(dimethylcarbamoyl)thiophen-3-yl)-3-p-tolylurea | 5-tert-Butyl-3-(3-p-tolyl-ureido)-thiophene-2-carboxylic acid dimethylamide | 5-tert-butyl-N,N-dimethyl-3-(3-p-tolylureido)thiophene-2-carboxamide | CHEMBL94156 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N3O2S |
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| Mol. Mass. | 359.486 |
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| SMILES | CN(C)C(=O)c1sc(cc1NC(=O)Nc1ccc(C)cc1)C(C)(C)C |
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| Structure | 
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