Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase Chk1 |
---|
Ligand | BDBM50375271 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_470513 (CHEMBL950057) |
---|
EC50 | 50±n/a nM |
---|
Citation | Hasvold, LA; Wang, L; Przytulinska, M; Xiao, Z; Chen, Z; Gu, WZ; Merta, PJ; Xue, J; Kovar, P; Zhang, H; Park, C; Sowin, TJ; Rosenberg, SH; Lin, NH Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors. Bioorg Med Chem Lett18:2311-5 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase Chk1 |
---|
Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
BDBM50375271 |
---|
n/a |
---|
Name | BDBM50375271 |
Synonyms: | CHEMBL272711 |
Type | Small organic molecule |
Emp. Form. | C26H26N4O6 |
Mol. Mass. | 490.5078 |
SMILES | COc1cc2NC(=O)c3ccc(cc3Nc2cc1CCC(=O)N(C)C)-c1ccc(c(OC)c1)[N+]([O-])=O |
Structure |
|