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TargetLanosterol 14-alpha demethylase
LigandBDBM50128548
Substrate/Competitorn/a
Meas. Tech.ChEMBL_470779 (CHEMBL934981)
IC50 342±n/a nM
Citation Ekins, S; Mankowski, DC; Hoover, DJ; Lawton, MP; Treadway, JL; Harwood, HJ Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos35:493-500 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lanosterol 14-alpha demethylase
Name:Lanosterol 14-alpha demethylase
Synonyms:CP51A_HUMAN | CYP51 | CYP51A1 | CYPLI | Cytochrome P450 51 | Cytochrome P450 51A1 | LDM | Lanosterol 14-alpha demethylase | P450-14DM | P45014DM | P450LI | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase
Type:Protein
Mol. Mass.:56817.21
Organism:Homo sapiens (Human)
Description:Q16850
Residue:509
Sequence:
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQL
PAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAA
ALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF
SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDS
WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIRYKRRSK
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BDBM50128548
n/a
NameBDBM50128548
Synonyms:1-(1-Biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole | 1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole (bifonazole) | 1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole( Bifanozole) | 1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole(Bifonazole) | 1-(biphenyl-4-yl-phenyl-methyl)-1H-imidazole | BIFONAZOLE | CHEMBL277535 | US9144538, Bifonazole | cid_2378
TypeSmall organic molecule
Emp. Form.C22H18N2
Mol. Mass.310.3917
SMILESc1cn(cn1)C(c1ccccc1)c1ccc(cc1)-c1ccccc1
Structure
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