| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50375324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_470971 (CHEMBL923040) |
|---|
| IC50 | 91200±n/a nM |
|---|
| Citation |  Benaamane, N; Nedjar-Kolli, B; Bentarzi, Y; Hammal, L; Geronikaki, A; Eleftheriou, P; Lagunin, A Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems. Bioorg Med Chem16:3059-66 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68692.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23219 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
|
|
|---|
| BDBM50375324 |
|---|
| n/a |
|---|
| Name | BDBM50375324 |
|---|
| Synonyms: | CHEMBL411087 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19N3O3 |
|---|
| Mol. Mass. | 373.4046 |
|---|
| SMILES | CC1=CC(OC(=O)N1c1ccc(C)cc1)=c1c(=C)[nH]n(-c2ccccc2)c1=O |w:3.2,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
