| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosine receptor A2b |
|---|
| Ligand | BDBM50375623 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_473541 (CHEMBL939195) |
|---|
| IC50 | 156±n/a nM |
|---|
| Citation |  Tabrizi, MA; Baraldi, PG; Preti, D; Romagnoli, R; Saponaro, G; Baraldi, S; Moorman, AR; Zaid, AN; Varani, K; Borea, PA 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists. Bioorg Med Chem16:2419-30 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosine receptor A2b |
|---|
| Name: | Adenosine receptor A2b |
|---|
| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 36341.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 332 |
|---|
| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
|
|
|
|---|
| BDBM50375623 |
|---|
| n/a |
|---|
| Name | BDBM50375623 |
|---|
| Synonyms: | CHEMBL259177 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26BrN7O3 |
|---|
| Mol. Mass. | 528.402 |
|---|
| SMILES | CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cc(C)n(CC(=O)Nc2ccc(Br)cc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
