Ki Summary

Reaction Details

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Target

Calcium/calmodulin-dependent protein kinase kinase 2

Ligand

BDBM50038199

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_473615 (CHEMBL940168)

IC50

200±n/a nM

Citation

Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A104:20523-8 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calcium/calmodulin-dependent protein kinase kinase 2

Name:

Calcium/calmodulin-dependent protein kinase kinase 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64746.61

Organism:

Homo sapiens (Human)

Description:

gi_27437015

Residue:

588

Sequence:

MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE

BDBM50038199

n/a

Name

BDBM50038199

Synonyms:

5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic acid | 5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid | 5-(N-2',5'-dihydroxybenzyl)aminosalicylic acid | CHEMBL319620 | Lavendustin C

Type

Small organic molecule

Emp. Form.

C14H13NO5

Mol. Mass.

275.2567

SMILES

OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O

Structure