| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 2 |
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| Ligand | BDBM50375643 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_473714 (CHEMBL936811) |
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| IC50 | 220±n/a nM |
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| Citation |  Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Müller, S; Bullock, AN; Schwaller, J; Sundström, M; Knapp, S A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A104:20523-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 2 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 2 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 2 (MEK2) | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 | ERK activator kinase 2 | MAP kinase kinase 2 | MAP2K2 | MAPK/ERK kinase 2 | MAPKK 2 | MEK2 | MKK2 | MP2K2_HUMAN | PRKMK2 | VHL-MAP2K1/MAP2K2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44423.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_13489054 |
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| Residue: | 400 |
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| Sequence: | MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ
GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP
PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL
KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
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| BDBM50375643 |
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| n/a |
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| Name | BDBM50375643 |
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| Synonyms: | CHEMBL261237 | SL-327 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12F3N3S |
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| Mol. Mass. | 335.347 |
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| SMILES | Nc1ccc(SC(=N)C(C#N)c2ccccc2C(F)(F)F)cc1 |
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| Structure | 
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