| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50095890 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_478587 (CHEMBL940856) |
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| IC50 | 40±n/a nM |
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| Citation |  Kim, SF; Huang, AS; Snowman, AM; Teuscher, C; Snyder, SH From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A104:3456-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55716.35 |
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| Organism: | RAT |
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| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
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| Residue: | 486 |
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| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
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| BDBM50095890 |
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| n/a |
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| Name | BDBM50095890 |
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| Synonyms: | 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol | 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol | CHEMBL716 | QUETIAPINE |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N3O2S |
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| Mol. Mass. | 383.507 |
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| SMILES | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 |t:13| |
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| Structure | 
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