| Reaction Details |
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 | Report a problem with these data |
| Target | Equilibrative nucleoside transporter 1 |
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| Ligand | BDBM50412017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_478938 (CHEMBL936364) |
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| IC50 | 77.62±n/a nM |
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| Citation |  Zhu, Z; Buolamwini, JK Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem16:3848-65 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Equilibrative nucleoside transporter 1 |
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| Name: | Equilibrative nucleoside transporter 1 |
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| Synonyms: | ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 50225.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 456 |
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| Sequence: | MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
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| BDBM50412017 |
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| n/a |
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| Name | BDBM50412017 |
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| Synonyms: | CHEMBL409320 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16Cl2N4O4S |
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| Mol. Mass. | 443.304 |
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| SMILES | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(CSc3ccc(Cl)cc3Cl)ncnc12 |
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| Structure | 
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