| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
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| Ligand | BDBM50376979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479201 (CHEMBL925952) |
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| IC50 | 107±n/a nM |
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| Citation |  Eckhardt, M; Hauel, N; Himmelsbach, F; Langkopf, E; Nar, H; Mark, M; Tadayyon, M; Thomas, L; Guth, B; Lotz, R 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors. Bioorg Med Chem Lett18:3158-62 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 4 |
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| Name: | Dipeptidyl peptidase 4 |
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| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 |
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| Type: | Enzyme |
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| Mol. Mass.: | 88271.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27487 |
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| Residue: | 766 |
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| Sequence: | MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
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| BDBM50376979 |
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| n/a |
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| Name | BDBM50376979 |
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| Synonyms: | CHEMBL401972 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N5O |
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| Mol. Mass. | 401.5041 |
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| SMILES | CC#CCn1c(cnc1N1CCCC(N)C1)C(=O)NCc1cccc2ccccc12 |w:13.14| |
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| Structure | 
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