Reaction Details |
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Target | Thrombopoietin receptor |
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Ligand | BDBM50219632 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_479602 (CHEMBL926798) |
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EC50 | 230±n/a nM |
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Citation | Reiter, LA; Jones, CS; Brissette, WH; McCurdy, SP; Abramov, YA; Bordner, J; DiCapua, FM; Munchhof, MJ; Rescek, DM; Samardjiev, IJ; Withka, JM Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists. Bioorg Med Chem Lett18:3000-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thrombopoietin receptor |
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Name: | Thrombopoietin receptor |
Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 71243.48 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_535587 |
Residue: | 635 |
Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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BDBM50219632 |
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n/a |
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Name | BDBM50219632 |
Synonyms: | CHEMBL393268 | N-(4-(4-chloro-2-fluorophenyl)thiazol-2-yl)-4-(pyrimidin-4-ylamino)benzamide |
Type | Small organic molecule |
Emp. Form. | C20H13ClFN5OS |
Mol. Mass. | 425.867 |
SMILES | Fc1cc(Cl)ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1 |
Structure |
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