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TargetProcathepsin L
LigandBDBM50377589
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479740 (CHEMBL929237)
IC50 118±n/a nM
Citation Mallari, JPShelat, AKosinski, ACaffrey, CRConnelly, MZhu, FMcKerrow, JHGuy, RK Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett18:2883-5 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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  Blast E-value cutoff:
BDBM50377589
n/a
NameBDBM50377589
Synonyms:CHEMBL261218
TypeSmall organic molecule
Emp. Form.C16H16FN3S
Mol. Mass.301.382
SMILESNC(=S)NN=C(CCc1ccccc1)c1cccc(F)c1 |w:4.3|
Structure
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