Reaction Details |
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Target | Aurora kinase A-interacting protein |
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Ligand | BDBM13534 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_531131 (CHEMBL974017) |
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Ki | 0.600000±n/a nM |
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Citation | McDermott, U; Sharma, SV; Dowell, L; Greninger, P; Montagut, C; Lamb, J; Archibald, H; Raudales, R; Tam, A; Lee, D; Rothenberg, SM; Supko, JG; Sordella, R; Ulkus, LE; Iafrate, AJ; Maheswaran, S; Njauw, CN; Tsao, H; Drew, L; Hanke, JH; Ma, XJ; Erlander, MG; Gray, NS; Haber, DA; Settleman, J Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A104:19936-41 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A-interacting protein |
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Name: | Aurora kinase A-interacting protein |
Synonyms: | AIP | AKIP | AKIP_HUMAN | AURKAIP1 | MRPS38 |
Type: | PROTEIN |
Mol. Mass.: | 22379.19 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_502288 |
Residue: | 199 |
Sequence: | MLLGRLTSQLLRAVPWAGGRPPWPVSGVLGSRVCGPLYSTSPAGPGRAASLPRKGAQLEL
EEMLVPRKMSVSPLESWLTARCFLPRLDTGTAGTVAPPQSYQCPPSQIGEGAEQGDEGVA
DAPQIQCKNVLKIRRRKMNHHKYRKLVKKTRFLRRKVQEGRLRRKQIKFEKDLRRIWLKA
GLKEAPEGWQTPKIYLRGK
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BDBM13534 |
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n/a |
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Name | BDBM13534 |
Synonyms: | CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide | VX-680 | VX680 | cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide |
Type | Small organic molecule |
Emp. Form. | C23H28N8OS |
Mol. Mass. | 464.586 |
SMILES | CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 |
Structure |
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