Ki Summary

Reaction Details

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Target

NAD-dependent protein deacetylase HST2

Ligand

BDBM50242436

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_533704 (CHEMBL973326)

3300±n/a nM

Citation

Smith, BC; Denu, JM Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases. J Biol Chem282:37256-65 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

NAD-dependent protein deacetylase HST2

Name:

NAD-dependent protein deacetylase HST2

Synonyms:

HST2 | HST2_YEAST | NAD-dependent deacetylase HST2

Type:

PROTEIN

Mol. Mass.:

39972.79

Organism:

Saccharomyces cerevisiae

Description:

ChEMBL_533704

Residue:

357

Sequence:

MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKL
PYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTL
ERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPA
IVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPR
KVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDN
SKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE

BDBM50242436

n/a

Name

BDBM50242436

Synonyms:

(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-ethanethioamidohexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid | CHEMBL501380

Type

Small organic molecule

Emp. Form.

C50H90N18O15S

Mol. Mass.

1215.426

SMILES

[#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](-[#6])=S)-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O |r|

Structure