Reaction Details |
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Target | DNA polymerase catalytic subunit |
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Ligand | BDBM50370476 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_488494 (CHEMBL991027) |
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IC50 | 3300±n/a nM |
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Citation | Schnute, ME; Brideau, RJ; Collier, SA; Cudahy, MM; Hopkins, TA; Knechtel, ML; Oien, NL; Sackett, RS; Scott, A; Stephan, ML; Wathen, MW; Wieber, JL Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition. Bioorg Med Chem Lett18:3856-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase catalytic subunit |
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Name: | DNA polymerase catalytic subunit |
Synonyms: | DPOL_HHV1K |
Type: | PROTEIN |
Mol. Mass.: | 136533.24 |
Organism: | Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus1) |
Description: | ChEMBL_488494 |
Residue: | 1235 |
Sequence: | MFSGGGGPLSPGGKSAARAASGFFAPAGPRGAGRGPPPCLRQNFYNPYLAPVGTQQKPTG
PTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGGDERDVLRVGSG
GFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHAYGMRAAQFHARFMDAITPTGT
VITLLGLTPEGHRVAVHVYGTRQYFYMNKEEVDRHLQCRAPRDLCERMAAALRESPGASF
RGISADHFEAEVVERTDVYYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDAT
TRFILDNPGFVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADNLAIEGGMSDLP
AYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLP
ESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLT
DIYKVPLDGYGRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKL
NAVAEAVLKDKKKDLSYRDIPAYYATGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSA
VARLAGINITRTIYDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAARED
EERPEEEGEDEDEREEGGGEREPEGARETAGRHVGYQGAKVLDPTSGFHVNPVVVFDFAS
LYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYLEIEVGGRRLFFVKAHVRESLLSILLRD
WLAMRKQIRSRIPQSSPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTI
GREMLLATREYVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAA
GLTAMGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRK
NNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRR
ITDPERDIQDFVLTAELSRHPRAYTNKRLAHLTVYYKLMARRAQVPSIKDRIPYVIVAQT
REVEETVARLAALRELDAAAPGDEPAPPAALPSPAKRPRETPSHADPPGGASKPRKLLVS
ELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIPEVWHPPD
DVAARLRAAGFGAVGAGATAEETRRMLHRAFDTLA
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BDBM50370476 |
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n/a |
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Name | BDBM50370476 |
Synonyms: | Combivir | ZIDOVUDINE TRIPHOSPHATE |
Type | Small organic molecule |
Emp. Form. | C10H16N5O13P3 |
Mol. Mass. | 507.181 |
SMILES | Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[P@@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| |
Structure |
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