Reaction Details |
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Target | Trifunctional purine biosynthetic protein adenosine-3 |
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Ligand | BDBM18796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_510466 (CHEMBL1006407) |
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IC50 | >20000±n/a nM |
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Citation | Deng, Y; Wang, Y; Cherian, C; Hou, Z; Buck, SA; Matherly, LH; Gangjee, A Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem51:5052-63 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Trifunctional purine biosynthetic protein adenosine-3 |
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Name: | Trifunctional purine biosynthetic protein adenosine-3 |
Synonyms: | GAR transformylase | Gart | PUR2_MOUSE |
Type: | PROTEIN |
Mol. Mass.: | 107504.27 |
Organism: | Mus musculus |
Description: | ChEMBL_497843 |
Residue: | 1010 |
Sequence: | MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQ
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIP
TAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSF
GAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAP
QVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLP
QLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEG
ELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN
LIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
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BDBM18796 |
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n/a |
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Name | BDBM18796 |
Synonyms: | (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid | LY231514 | Pemetrexed |
Type | Small organic molecule |
Emp. Form. | C20H21N5O6 |
Mol. Mass. | 427.4106 |
SMILES | Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
Structure |
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