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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Trifunctional purine biosynthetic protein adenosine-3 | ||
| Ligand | BDBM50005518 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_510467 (CHEMBL1006408) | ||
| IC50 | 14±n/a nM | ||
| Citation |  Deng, Y; Wang, Y; Cherian, C; Hou, Z; Buck, SA; Matherly, LH; Gangjee, A Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem51:5052-63 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Trifunctional purine biosynthetic protein adenosine-3 | |||
| Name: | Trifunctional purine biosynthetic protein adenosine-3 | ||
| Synonyms: | GAR Tfase | GAR transformylase | GART | Glycinamide ribonucleotide formyltransferase (GARFTase) | Glycinamide ribonucleotide transformylase (GAR Tfase) | PGFT | PRGS | PUR2_HUMAN | Thymidylate synthase/GAR transformylase/AICAR transformylase | ||
| Type: | Protein | ||
| Mol. Mass.: | 107768.47 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P22102 | ||
| Residue: | 1010 | ||
| Sequence: |
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| BDBM50005518 | |||
| n/a | |||
| Name | BDBM50005518 | ||
| Synonyms: | (S)-2-(4-(2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzamido)pentanedioic acid | (S)-2-(4-(2-((R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl)ethyl)benzamido)pentanedioic acid | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | (S)-2-{(R)-4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | (S)-2-{(S)-4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | (S)-2-{4-[2-((R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | (S)-2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | CHEMBL142806 | LOMETREXOL | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25N5O6 | ||
| Mol. Mass. | 443.4531 | ||
| SMILES | Nc1nc2NCC(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1 |r| | ||
| Structure | 
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