| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Ligand | BDBM50245245 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_511133 (CHEMBL999604) |
|---|
| IC50 | 0.8±n/a nM |
|---|
| Citation |  Kodimuthali, A; Jabaris, SS; Pal, M Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. J Med Chem51:5471-89 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE2 | PDE46 | PDE4A | PDE4A_HUMAN | Phosphodiesterase 4 (PDE4) | Phosphodiesterase 4A | Phosphodiesterase 4A (PDE4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98113.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27815 |
|---|
| Residue: | 886 |
|---|
| Sequence: | MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
|---|
| BDBM50245245 |
|---|
| n/a |
|---|
| Name | BDBM50245245 |
|---|
| Synonyms: | 4-{2-(3,4-Bis-difluoromethoxy-phenyl)-2-[4-(1-methyl-1-phenyl-ethylamino)-phenyl]-ethyl}-pyridin-1-ol anion | CHEMBL452578 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H28F4N2O3 |
|---|
| Mol. Mass. | 540.5485 |
|---|
| SMILES | CC(C)(Nc1ccc(cc1)C(Cc1cc[n+]([O-])cc1)c1ccc(OC(F)F)c(OC(F)F)c1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
