Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50263314 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535411 (CHEMBL984440) |
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Ki | 3464±n/a nM |
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Citation | Strappaghetti, G; Mastrini, L; Lucacchini, A; Giannaccini, G; Betti, L; Fabbrini, L Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: further validation of a pharmacophore model for alpha(1)-adrenoceptor antagonists. Bioorg Med Chem Lett18:5140-5 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50263314 |
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n/a |
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Name | BDBM50263314 |
Synonyms: | 2-(3-(1H-imidazol-1-yl)-6-oxopyridazin-1(6H)-yl)-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)acetamide | CHEMBL478039 |
Type | Small organic molecule |
Emp. Form. | C22H27N7O3 |
Mol. Mass. | 437.4949 |
SMILES | COc1ccccc1N1CCN(CCNC(=O)Cn2nc(ccc2=O)-n2ccnc2)CC1 |
Structure |
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