| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50263335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_535587 (CHEMBL987061) |
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| EC50 | 148±n/a nM |
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| Citation |  Alper, PB; Marsilje, TH; Mutnick, D; Lu, W; Chatterjee, A; Roberts, MJ; He, Y; Karanewsky, DS; Chow, D; Lao, J; Gerken, A; Tuntland, T; Liu, B; Chang, J; Gordon, P; Seidel, HM; Tian, SS Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Bioorg Med Chem Lett18:5255-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50263335 |
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| n/a |
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| Name | BDBM50263335 |
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| Synonyms: | 2-hydroxy-9-(3-(trifluoromethyl)phenyl)-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid | CHEMBL515795 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16F3NO3 |
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| Mol. Mass. | 423.3839 |
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| SMILES | OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)-c3cccc(c3)C(F)(F)F)-c2cc1O |
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| Structure | 
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