Ki Summary

Reaction Details

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Target

Somatostatin receptor type 5

Ligand

BDBM50254260

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_560342 (CHEMBL1009182)

IC50

12±n/a nM

Citation

Feytens, D; De Vlaeminck, M; Cescato, R; Tourwé, D; Reubi, JC Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities. J Med Chem52:95-104 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Somatostatin receptor type 5

Name:

Somatostatin receptor type 5

Synonyms:

SOMATOSTATIN SST5 | SS-5-R | SS5-R | SS5R | SSR5_HUMAN | SSTR5 | Somatostatin receptor type 5 (SSTR5)

Type:

Enzyme

Mol. Mass.:

39218.02

Organism:

Homo sapiens (Human)

Description:

P35346

Residue:

364

Sequence:

MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTL
VIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDG
VNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADV
QEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRR
RSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCAN
PVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQ
TSKL

BDBM50254260

n/a

Name

BDBM50254260

Synonyms:

(2S,5R,8S,11S,14S,19S,E)-5-((1H-indol-3-yl)methyl)-19-((R)-2-amino-3-phenylpropanamido)-8-(4-aminobutyl)-2-benzyl-11-(4-(benzyloxy)benzyl)-N-((2R,3R)-1,3-dihydroxybutan-2-yl)-3,6,9,12,20-pentaoxo-1,4,7,10,13-pentaazacycloicos-16-ene-14-carboxamide | CHEMBL503472

Type

Small organic molecule

Emp. Form.

C63H76N10O10

Mol. Mass.

1133.3385

SMILES

C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1C\C=C\C[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(OCc3ccccc3)cc2)C(=O)N1 |r,t:11|

Structure