| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50253580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_538598 (CHEMBL1026636) |
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| IC50 | 14.5±n/a nM |
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| Citation |  Gangjee, A; Adair, OO; Pagley, M; Queener, SF N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. J Med Chem51:6195-200 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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| BDBM50253580 |
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| n/a |
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| Name | BDBM50253580 |
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| Synonyms: | 2,4-Diamino-6-[N-(beta-naphthyl)-N-ethylamino]quinazoline | CHEMBL522678 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5 |
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| Mol. Mass. | 343.4249 |
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| SMILES | CCN(Cc1ccc2ccccc2c1)c1ccc2nc(N)nc(N)c2c1 |
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| Structure | 
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