Ki Summary

Reaction Details

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Target

Small conductance calcium-activated potassium channel protein 3

Ligand

BDBM50377979

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_494975 (CHEMBL1008047)

21000±n/a nM

Citation

Sørensen, US; Strøbaek, D; Christophersen, P; Hougaard, C; Jensen, ML; Nielsen, E�; Peters, D; Teuber, L Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem51:7625-34 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Small conductance calcium-activated potassium channel protein 3

Name:

Small conductance calcium-activated potassium channel protein 3

Synonyms:

KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel

Type:

PROTEIN

Mol. Mass.:

81476.29

Organism:

Rattus norvegicus

Description:

ChEMBL_494975

Residue:

732

Sequence:

MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQ
LQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAI
LHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCK
YSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNA
THNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMV
IETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMT
YERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIA
RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVR
VCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVV
AVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRK
HQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSL
ESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISST
SFPTPYTSSSSC

BDBM50377979

n/a

Name

BDBM50377979

Synonyms:

PENUCURONIUM

Type

Small organic molecule

Emp. Form.

C36H62N2O4

Mol. Mass.

586.8874

SMILES

CC(=O)O[C@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@H](OC(C)=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)C[C@@H]1[N+]1(C)CCCCC1)[N+]1(C)CCCCC1 |r|

Structure