| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM7478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_563811 (CHEMBL994323) |
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| IC50 | 1200±n/a nM |
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| Citation |  Gray, NS; Wodicka, L; Thunnissen, AM; Norman, TC; Kwon, S; Espinoza, FH; Morgan, DO; Barnes, G; LeClerc, S; Meijer, L; Kim, SH; Lockhart, DJ; Schultz, PG Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science281:533-538 (1998) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC28 | CDK1 | CDK1_YEAST | Cell division control protein 28 | HSL5 | SRM5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34067.63 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_563811 |
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| Residue: | 298 |
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| Sequence: | MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREIS
LLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQL
CKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAP
EVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIV
YLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES
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| BDBM7478 |
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| n/a |
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| Name | BDBM7478 |
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| Synonyms: | 2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino}-9-isopropyl-9H-purin-6-yl)amino]benzoic acid | 2-chloro-4-[(2-{[(2R)-1-hydroxy-3-methylbutan-2-yl]amino}-9-(propan-2-yl)-9H-purin-6-yl)amino]benzoic acid | CHEMBL23254 | Purvalanol B |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25ClN6O3 |
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| Mol. Mass. | 432.904 |
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| SMILES | CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1 |r| |
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| Structure | 
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