| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heat shock protein HSP 90-beta |
|---|
| Ligand | BDBM50265817 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_543925 (CHEMBL1020360) |
|---|
| IC50 | 80±n/a nM |
|---|
| Citation |  Taldone, T; Sun, W; Chiosis, G Discovery and development of heat shock protein 90 inhibitors. Bioorg Med Chem17:2225-35 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Heat shock protein HSP 90-beta |
|---|
| Name: | Heat shock protein HSP 90-beta |
|---|
| Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) |
|---|
| Type: | Molecular Chaperone |
|---|
| Mol. Mass.: | 83229.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08238 |
|---|
| Residue: | 724 |
|---|
| Sequence: | MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD
|
|
|
|---|
| BDBM50265817 |
|---|
| n/a |
|---|
| Name | BDBM50265817 |
|---|
| Synonyms: | CHEMBL526127 | Pochonin D |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19ClO5 |
|---|
| Mol. Mass. | 350.793 |
|---|
| SMILES | C[C@@H]1C\C=C\CCC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |r,w:8.8,t:3| |
|---|
| Structure | 
|
|---|
Search and Browse
