Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cannabinoid receptor 1 | ||
| Ligand | BDBM50258653 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_523688 (CHEMBL997203) | ||
| Ki | 300±n/a nM | ||
| Citation |  Manera, C; Saccomanni, G; Adinolfi, B; Benetti, V; Ligresti, A; Cascio, MG; Tuccinardi, T; Lucchesi, V; Martinelli, A; Nieri, P; Masini, E; Di Marzo, V; Ferrarini, PL Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists. J Med Chem52:3644-51 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cannabinoid receptor 1 | |||
| Name: | Cannabinoid receptor 1 | ||
| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 52868.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21554 | ||
| Residue: | 472 | ||
| Sequence: |
| ||
| BDBM50258653 | |||
| n/a | |||
| Name | BDBM50258653 | ||
| Synonyms: | CHEMBL512063 | trans-N-(4-Methylcyclohexyl)-1-(p-fluorobenzyl)-1,8-naphthyridin-2(1H)-on-3-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24FN3O2 | ||
| Mol. Mass. | 393.454 | ||
| SMILES | C[C@H]1CC[C@@H](CC1)NC(=O)c1cc2cccnc2n(Cc2ccc(F)cc2)c1=O |r,wU:4.7,wD:1.0,(18.09,5.74,;16.75,4.97,;15.42,5.74,;14.08,4.97,;14.08,3.44,;15.42,2.67,;16.75,3.43,;12.75,2.67,;11.42,3.44,;11.41,4.98,;10.09,2.66,;8.73,3.44,;7.4,2.65,;6.06,3.42,;4.73,2.64,;4.73,1.1,;6.07,.33,;7.4,1.1,;8.75,.33,;8.75,-1.21,;10.09,-1.97,;10.09,-3.5,;11.42,-4.27,;12.75,-3.49,;14.09,-4.25,;12.74,-1.96,;11.42,-1.2,;10.09,1.11,;11.43,.34,)| | ||
| Structure | 
| ||