| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase alpha-1 |
|---|
| Ligand | BDBM50250137 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_498323 (CHEMBL973461) |
|---|
| IC50 | 34900±n/a nM |
|---|
| Citation |  Hall, MD; Salam, NK; Hellawell, JL; Fales, HM; Kensler, CB; Ludwig, JA; Szakács, G; Hibbs, DE; Gottesman, MM Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem52:3191-204 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ribosomal protein S6 kinase alpha-1 |
|---|
| Name: | Ribosomal protein S6 kinase alpha-1 |
|---|
| Synonyms: | 90 kDa ribosomal protein S6 kinase 1 | KS6A1_HUMAN | MAP kinase-activated protein kinase 1a | MAPKAPK1A | RPS6KA1 | RPS6KA1(Kin.Dom.1 - N-terminal) | RPS6KA1(Kin.Dom.2 - C-terminal) | RSK-1 | RSK1 | Ribosomal S6 Kinase 1 (RSK-1) | Ribosomal S6 kinase 1 | Ribosomal S6 kinase 1 (RSK1) | Ribosomal protein S6 kinase alpha 1 | Ribosomal protein S6 kinase alpha-1 | Ribosomal protein S6 kinase alpha-1 (RSK1) | S6K-alpha 1 | p90-RSK 1 | p90RSK | p90S6K | pp90RSK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 82736.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 735 |
|---|
| Sequence: | MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS
HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN
HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS
LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHS
HSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRN
PANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTP
KDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVV
KETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKDVYD
DGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSN
ILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL
GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP
HQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESS
ILAQRRVRKLPSTTL
|
|
|
|---|
| BDBM50250137 |
|---|
| n/a |
|---|
| Name | BDBM50250137 |
|---|
| Synonyms: | 1-Isatin-4-(4'methoxyphenyl)thiosemicarbazone | CHEMBL504574 | NSC-73306 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14N4O2S |
|---|
| Mol. Mass. | 326.373 |
|---|
| SMILES | COc1ccc(NC(=S)NN=C2C(=O)Nc3ccccc23)cc1 |w:10.9| |
|---|
| Structure | 
|
|---|
Search and Browse
