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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249142 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499970 (CHEMBL1019340) | ||
| Ki | 22.6±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50249142 | |||
| n/a | |||
| Name | BDBM50249142 | ||
| Synonyms: | CHEMBL514455 | N-(4,5-dimethyl-1,3-thiazol-2-yl)-15-methyltetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22N2OS | ||
| Mol. Mass. | 374.499 | ||
| SMILES | Cc1nc(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc32)sc1C |TLB:8:7:11.16:18.23,15:16:9.7:18.23,19:18:11.16:9.7,THB:5:7:11.16:18.23,(38.26,-10.94,;36.85,-11.59,;36.55,-13.1,;35.01,-13.28,;34.26,-14.62,;32.71,-14.64,;31.93,-13.31,;31.96,-15.98,;30.62,-15.21,;32.47,-16.75,;32.47,-18.94,;30.61,-19.46,;29.26,-20.23,;27.93,-19.46,;27.93,-17.91,;29.26,-17.14,;30.57,-18.06,;31.96,-17.4,;33.49,-18.29,;34.76,-17.55,;36.04,-18.28,;36.05,-19.77,;34.77,-20.51,;33.49,-19.77,;34.38,-11.88,;35.51,-10.83,;35.33,-9.3,)| | ||
| Structure | 
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