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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249148 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499971 (CHEMBL1019341) | ||
| EC50 | 118.8±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50249148 | |||
| n/a | |||
| Name | BDBM50249148 | ||
| Synonyms: | 8-bromo-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL474188 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17BrN2OS | ||
| Mol. Mass. | 425.341 | ||
| SMILES | CC1(CC2(Br)c3ccccc3C1c1ccccc21)C(=O)Nc1nccs1 |TLB:0:1:5.10:12.17,9:10:2.1:12.17,13:12:5.10:2.1,THB:18:1:5.10:12.17,(-7.97,-14.39,;-6.62,-15.17,;-6.12,-15.94,;-6.11,-18.13,;-6.12,-19.67,;-7.98,-18.65,;-9.32,-19.42,;-10.66,-18.65,;-10.66,-17.1,;-9.33,-16.33,;-8.01,-17.25,;-6.62,-16.59,;-5.09,-17.48,;-3.81,-16.74,;-2.53,-17.48,;-2.53,-18.96,;-3.81,-19.7,;-5.09,-18.96,;-5.87,-13.83,;-6.65,-12.5,;-4.32,-13.81,;-3.57,-12.46,;-2.03,-12.28,;-1.72,-10.77,;-3.07,-10.01,;-4.2,-11.06,)| | ||
| Structure | 
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