Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249108 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499972 (CHEMBL1019342) | ||
| EC50 | >5000±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50249108 | |||
| n/a | |||
| Name | BDBM50249108 | ||
| Synonyms: | 15-methyl-8-nitro-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL516386 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17N3O3S | ||
| Mol. Mass. | 391.443 | ||
| SMILES | CC1(CC2(c3ccccc3C1c1ccccc21)[N+]([O-])=O)C(=O)Nc1nccs1 |TLB:0:1:4.9:11.16,8:9:2.1:11.16,12:11:4.9:2.1,THB:20:1:4.9:11.16,(18.83,.65,;20.18,-.12,;20.69,-.89,;20.69,-3.09,;18.83,-3.61,;17.48,-4.38,;16.14,-3.61,;16.15,-2.06,;17.48,-1.29,;18.79,-2.21,;20.18,-1.54,;21.71,-2.44,;22.99,-1.7,;24.27,-2.43,;24.27,-3.92,;22.99,-4.66,;21.71,-3.92,;20.68,-4.62,;19.34,-5.38,;22,-5.4,;20.94,1.22,;20.15,2.55,;22.48,1.24,;23.24,2.58,;24.78,2.76,;25.08,4.27,;23.74,5.03,;22.6,3.99,)| | ||
| Structure | 
| ||