Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMethionine Aminopeptidase Type 1 (MetAP1)
LigandBDBM17847
Substrate/Competitorn/a
Meas. Tech.ChEMBL_576147
IC50 2000±n/a nM
Citation Sashidhara KVWhite KNCrews P A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products. J Nat Prod 72:588-603 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methionine Aminopeptidase Type 1 (MetAP1)
Name:Aminopeptidase
Synonyms:MAP 1 | MetAP 1 | Peptidase M 1
Type:Enzyme
Mol. Mass.:43220.79
Organism:Homo sapiens (Human)
Description:MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17847
n/a
NameBDBM17847
Synonyms:CHEMBL327579 | pyridine-2-carboxylic acid inhibitor, 1 | tert-butyl N-[2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate
TypeSmall organic molecule
Emp. Form.C14H16N4O3S
Mol. Mass.320.367
SMILESCC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: