Reaction Details |
| Report a problem with these data |
Target | Endothelin-converting enzyme 1 |
---|
Ligand | BDBM50298110 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_585131 (CHEMBL1060020) |
---|
IC50 | 2420±n/a nM |
---|
Citation | Olimpieri, F; Tambaro, S; Fustero, S; Lazzari, P; Sanchez-Roselló, M; Pani, L; Volonterio, A; Zanda, M Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors. Bioorg Med Chem Lett19:4715-9 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin-converting enzyme 1 |
---|
Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
|
|
|
BDBM50298110 |
---|
n/a |
---|
Name | BDBM50298110 |
Synonyms: | 2-(4,4,5,5,5-Pentafluoro-3-mercapto-pentanoylamino)-3-phenyl-propionic acid | CHEMBL558146 |
Type | Small organic molecule |
Emp. Form. | C14H14F5NO3S |
Mol. Mass. | 371.323 |
SMILES | OC(=O)C(Cc1ccccc1)NC(=O)CC(S)C(F)(F)C(F)(F)F |
Structure |
|