| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50298111 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_585131 (CHEMBL1060020) |
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| IC50 | >10000±n/a nM |
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| Citation |  Olimpieri, F; Tambaro, S; Fustero, S; Lazzari, P; Sanchez-Roselló, M; Pani, L; Volonterio, A; Zanda, M Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors. Bioorg Med Chem Lett19:4715-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 87155.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42892 |
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| Residue: | 770 |
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| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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| BDBM50298111 |
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| n/a |
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| Name | BDBM50298111 |
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| Synonyms: | 3-(4-Hydroxy-phenyl)-2-[3-phenyl-2-(4,4,4-trifluoro-3-mercapto-butyrylamino)-propionylamino]-propionic acid | CHEMBL560409 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F3N2O5S |
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| Mol. Mass. | 484.489 |
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| SMILES | OC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccccc1)NC(=O)CC(S)C(F)(F)F |
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| Structure | 
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