| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase LCK |
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| Ligand | BDBM50298225 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_587115 (CHEMBL1051325) |
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| IC50 | 460±n/a nM |
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| Citation |  Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P The selectivity of protein kinase inhibitors: a further update. Biochem J408:297-315 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase LCK |
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| Name: | Proto-oncogene tyrosine-protein kinase LCK |
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| Synonyms: | LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57927.84 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_806408 |
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| Residue: | 509 |
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| Sequence: | MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER
PEDRPTFDYLRSVLDDFFTATEGQYQPQP
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| BDBM50298225 |
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| n/a |
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| Name | BDBM50298225 |
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| Synonyms: | CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104, Compound 5d | US11247972, Compound 5d | US9765037, Compound 5d |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N5 |
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| Mol. Mass. | 331.4142 |
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| SMILES | CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12 |
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| Structure | 
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