| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50175387 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_591454 (CHEMBL1055306) |
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| IC50 | 3.00±n/a nM |
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| Citation |  Marquis, RW; Lago, AM; Callahan, JF; Rahman, A; Dong, X; Stroup, GB; Hoffman, S; Gowen, M; DelMar, EG; Van Wagenen, BC; Logan, S; Shimizu, S; Fox, J; Nemeth, EF; Roethke, T; Smith, BR; Ward, KW; Bhatnagar, P Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. J Med Chem52:6599-605 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70322.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31645 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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| BDBM50175387 |
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| n/a |
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| Name | BDBM50175387 |
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| Synonyms: | (R)-2-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile | 2-[((2R)-3-{[1,1-Dimethyl-2-(2-naphthalenyl)ethyl]amino}-2-hydroxypropyl)oxy]benzonitrile | CHEMBL382741 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O2 |
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| Mol. Mass. | 374.4754 |
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| SMILES | CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccccc1C#N |
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| Structure | 
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