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TargetMalate dehydrogenase, mitochondrial
LigandBDBM50300059
Substrate/Competitorn/a
Meas. Tech.ChEMBL_593431 (CHEMBL1041437)
IC50 1600±n/a nM
Citation Becker, AKohfeld, SLader, APreu, LPies, TWieking, KFerandin, YKnockaert, MMeijer, LKunick, C Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). Eur J Med Chem45:335-42 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Malate dehydrogenase, mitochondrial
Name:Malate dehydrogenase, mitochondrial
Synonyms:MDH2 | MDHM_HUMAN
Type:PROTEIN
Mol. Mass.:35512.45
Organism:Homo sapiens (Human)
Description:ChEMBL_1456625
Residue:338
Sequence:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50300059
n/a
NameBDBM50300059
Synonyms:5-Benzyl-9-tert-butyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one | CHEMBL575106
TypeSmall organic molecule
Emp. Form.C27H26N2O
Mol. Mass.394.5081
SMILESCC(C)(C)c1ccc2[nH]c-3c(CC(=O)N(Cc4ccccc4)c4ccccc-34)c2c1
Structure
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