Reaction Details |
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Target | HTH-type transcriptional regulator ExsA |
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Ligand | BDBM50378357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_592474 (CHEMBL1043190) |
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IC50 | 3500±n/a nM |
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Citation | Kim, OK; Garrity-Ryan, LK; Bartlett, VJ; Grier, MC; Verma, AK; Medjanis, G; Donatelli, JE; Macone, AB; Tanaka, SK; Levy, SB; Alekshun, MN N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. J Med Chem52:5626-34 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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HTH-type transcriptional regulator ExsA |
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Name: | HTH-type transcriptional regulator ExsA |
Synonyms: | EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA |
Type: | PROTEIN |
Mol. Mass.: | 31648.37 |
Organism: | Pseudomonas aeruginosa |
Description: | ChEMBL_635526 |
Residue: | 278 |
Sequence: | MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVR
RGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAG
CVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKH
YLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIA
MEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
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BDBM50378357 |
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n/a |
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Name | BDBM50378357 |
Synonyms: | CHEMBL575329 |
Type | Small organic molecule |
Emp. Form. | C22H15FN4O4 |
Mol. Mass. | 418.3773 |
SMILES | On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)\C=C\c2ccc(F)cc2)cc1 |
Structure |
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